410 research outputs found
Some Comments on an MeV Cold Dark Matter Scenario
We discuss several aspects of astroparticle physics pertaining to a new model
with MeV cold dark matter particles, which annihilate to electron-positron
pairs in a manner yielding the correct CDM density required today, and
explaining the enhanced electron-positron annihilation line from the center of
the Galaxy. We note that the mass of the vector meson mediating the
annihilations, should exceed the mass of CDM particle, and comment on possible
enhancement due to CDM clustering, on the detectability of the new CDM, and on
particle physics models incorporating this scenario.Comment: 13 pages, 2 figures. v2 - Added some remarks regarding a more
stringent mass bound. References added, some typos corrected. v3 - Added a
comment regarding the invalidity of perturbative calculation in the case of a
very small coupling g'. Removed the comment regarding the smallness of the
angular width of the 511 keV lin
Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T
Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7 T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in ‘arterial’ and ‘venous’ blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between ‘arterial’ and ‘venous’ contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms
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